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Assay Detail

CHEMBL837825

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested for its cytotoxicity by inhibiting the growth of A-549 cell line after 72 h
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Intermediate

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies.
Miller ML, Roller EE, Wu X, Leece BA, Goldmacher VS, Chari RV, Ojima I.
Bioorg Med Chem Lett (2004) 14 : 4079 -4082
PubMed 15225730 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 9.61 10.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL361715 1 10.52
CHEMBL364995 1 10.52
CHEMBL362146 1 10.40
CHEMBL386116 1 10.10
CHEMBL277105 1 10.00
CHEMBL427327 1 9.70
CHEMBL364801 1 9.44
CHEMBL153231 1 9.10
CHEMBL183521 1 9.05
CHEMBL3545252 DOCETAXEL 4.0 1 9.00
CHEMBL184919 1 9.00
CHEMBL428647 PACLITAXEL 4.0 1 8.52
CHEMBL427593 1 -
CHEMBL364180 1 -
CHEMBL364396 1 -
CHEMBL185273 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL361715 IC50 = 0.03 nM 10.52
CHEMBL364995 IC50 = 0.03 nM 10.52
CHEMBL362146 IC50 = 0.04 nM 10.40
CHEMBL386116 IC50 = 0.08 nM 10.10
CHEMBL277105 IC50 = 0.1 nM 10.00
CHEMBL427327 IC50 = 0.2 nM 9.70
CHEMBL364801 IC50 = 0.36 nM 9.44
CHEMBL153231 IC50 = 0.8 nM 9.10
CHEMBL183521 IC50 = 0.9 nM 9.05
CHEMBL3545252 DOCETAXEL IC50 = 1.0 nM 9.00
CHEMBL184919 IC50 = 1.0 nM 9.00
CHEMBL428647 PACLITAXEL IC50 = 3.0 nM 8.52
CHEMBL427593 IC50 > 3.0 nM -
CHEMBL364180 IC50 > 3.0 nM -
CHEMBL364396 IC50 > 3.0 nM -
CHEMBL185273 IC50 > 3.0 nM -