Assay Detail
Functional
CHEMBL837868
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In vitro inhibition of estradiol-stimulated MCF-7 breast cancer cell proliferation
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cancer cell lines |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.97 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367350 | — | — | 1 | 9.70 |
| CHEMBL180792 | — | — | 2 | 9.52 |
| CHEMBL182980 | — | — | 1 | 9.40 |
| CHEMBL182794 | — | — | 1 | 9.40 |
| CHEMBL369545 | — | — | 1 | 9.40 |
| CHEMBL183371 | — | — | 1 | 9.40 |
| CHEMBL183489 | — | — | 1 | 9.40 |
| CHEMBL367574 | — | — | 1 | 9.30 |
| CHEMBL179852 | — | — | 1 | 9.30 |
| CHEMBL183344 | — | — | 1 | 9.30 |
| CHEMBL182887 | — | — | 1 | 9.15 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 9.10 |
| CHEMBL183584 | — | — | 1 | 9.05 |
| CHEMBL183049 | — | — | 1 | 9.00 |
| CHEMBL2113027 | — | — | 1 | 8.92 |
| CHEMBL183092 | — | — | 1 | 8.89 |
| CHEMBL183388 | — | — | 1 | 8.80 |
| CHEMBL183263 | — | — | 1 | 8.70 |
| CHEMBL181944 | — | — | 1 | 8.64 |
| CHEMBL184202 | — | — | 1 | 8.59 |
| CHEMBL304552 | — | — | 1 | 8.55 |
| CHEMBL183086 | — | — | 1 | 8.51 |
| CHEMBL362623 | — | — | 1 | 8.48 |
| CHEMBL361601 | — | — | 1 | 8.46 |
| CHEMBL427324 | — | — | 1 | 8.42 |
| CHEMBL361751 | — | — | 1 | 8.39 |
| CHEMBL183044 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367350 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL180792 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL182980 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL182794 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL369545 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL183371 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL183489 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL367574 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL180792 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL179852 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL183344 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL182887 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL183584 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL183049 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2113027 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL183092 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL183388 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL183263 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL181944 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL184202 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL304552 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL183086 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL362623 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL361601 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL427324 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL361751 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL183044 | — | IC50 | = | 9.1 | nM | 8.04 |