Assay Detail
Functional
CHEMBL837986
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against cell proliferation in various human MDA-MB-231 (breast carcinoma) tumor cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.20 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363130 | — | — | 1 | 6.26 |
| CHEMBL191003 | JNJ-7706621 | — | 1 | 6.23 |
| CHEMBL190643 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363130 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL190643 | — | IC50 | = | 760.0 | nM | 6.12 |