Assay Detail
Functional
CHEMBL838013
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of quinpirole stimulation of mitogenesis at human dopamine D2 receptors expressed in Chinese hamster ovary cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ovary |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.29 | 7.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL194493 | — | — | 1 | 7.86 |
| CHEMBL370713 | — | — | 1 | 7.21 |
| CHEMBL180060 | — | — | 1 | 6.79 |
| CHEMBL180010 | — | — | 1 | - |
| CHEMBL414838 | — | — | 1 | - |
| CHEMBL175734 | — | — | 1 | - |
| CHEMBL366904 | — | — | 1 | - |
| CHEMBL300780 | — | — | 1 | - |
| CHEMBL59725 | — | — | 1 | - |
| CHEMBL139926 | — | — | 1 | - |
| CHEMBL71327 | — | — | 1 | - |
| CHEMBL195057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL194493 | — | EC50 | = | 13.8 | nM | 7.86 |
| CHEMBL370713 | — | EC50 | = | 61.8 | nM | 7.21 |
| CHEMBL180060 | — | EC50 | = | 162.0 | nM | 6.79 |
| CHEMBL180010 | — | EC50 | = | 80.9 | — | - |
| CHEMBL414838 | — | EC50 | = | 36.4 | — | - |
| CHEMBL175734 | — | EC50 | = | 254.0 | — | - |
| CHEMBL366904 | — | EC50 | = | 111.0 | — | - |
| CHEMBL300780 | — | EC50 | = | 1280.0 | — | - |
| CHEMBL59725 | — | EC50 | = | 95.0 | — | - |
| CHEMBL139926 | — | EC50 | = | 118.0 | — | - |
| CHEMBL71327 | — | EC50 | = | 16.1 | — | - |
| CHEMBL195057 | — | EC50 | = | 8.29 | — | - |