Assay Detail
Functional
CHEMBL838106
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Cytotoxicity against HeLa cell lines
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, electrochemistry, and bioactivity of the cyanobacterial calothrixins and related quinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.35 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435295 | CALOTHRIXIN A | — | 1 | 6.92 |
| CHEMBL361701 | — | — | 1 | 6.82 |
| CHEMBL362573 | CALOTHRIXIN B | — | 1 | 6.62 |
| CHEMBL188310 | — | — | 1 | 6.43 |
| CHEMBL365217 | — | — | 1 | 6.38 |
| CHEMBL362886 | BENZOCARBAZOLEDIONE | — | 1 | 6.37 |
| CHEMBL185972 | — | — | 1 | 5.80 |
| CHEMBL590 | MENADIONE | 4.0 | 1 | 5.43 |
| CHEMBL363447 | — | — | 1 | - |
| CHEMBL363112 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435295 | CALOTHRIXIN A | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL361701 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL362573 | CALOTHRIXIN B | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL188310 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL365217 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL362886 | BENZOCARBAZOLEDIONE | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL185972 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL590 | MENADIONE | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL363447 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL363112 | — | EC50 | > | 50000.0 | nM | - |