Assay Detail
Functional
CHEMBL838111
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Anti-proliferative activity against HeLa cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.18 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425904 | — | — | 1 | 5.82 |
| CHEMBL193117 | — | — | 1 | 4.98 |
| CHEMBL195373 | — | — | 1 | 4.73 |
| CHEMBL426811 | — | — | 1 | - |
| CHEMBL192161 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425904 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL193117 | — | EC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL195373 | — | EC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL426811 | — | EC50 | > | 59000.0 | nM | - |
| CHEMBL192161 | — | EC50 | > | 59000.0 | nM | - |