Assay Detail
Functional
CHEMBL838119
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Effective concentration againstHBV in Hep G2.2.15 cells
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 2.2.15 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.84 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372855 | — | — | 2 | 6.40 |
| CHEMBL363136 | — | — | 1 | 6.29 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 5.25 |
| CHEMBL372283 | CARBOVIR | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372855 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL363136 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL372855 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL372283 | CARBOVIR | EC50 | = | 10000.0 | nM | 5.00 |