Assay Detail
Binding
CHEMBL838573
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In vitro binding affinity for Alpha-2a adrenergic receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.21 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 7.13 |
| CHEMBL180059 | — | — | 1 | 6.81 |
| CHEMBL298406 | ECOPIPAM | 3.0 | 1 | 6.14 |
| CHEMBL366839 | — | — | 1 | 6.14 |
| CHEMBL368926 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL180059 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL298406 | ECOPIPAM | Ki | = | 731.0 | nM | 6.14 |
| CHEMBL366839 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL368926 | — | Ki | = | 14600.0 | nM | 4.84 |