Assay Detail
Binding
CHEMBL838598
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In vitro displacement of [3H]GBR-12935 from human dopamine transporter expressed in HEK293 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.46 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192619 | — | — | 1 | 5.67 |
| CHEMBL365812 | — | — | 1 | 5.54 |
| CHEMBL425010 | — | — | 1 | 5.45 |
| CHEMBL190937 | — | — | 1 | 5.44 |
| CHEMBL192528 | — | — | 1 | 5.35 |
| CHEMBL366170 | — | — | 1 | 5.28 |
| CHEMBL23034 | — | — | 1 | - |
| CHEMBL106939 | DASB | 1.0 | 1 | - |
| CHEMBL22183 | — | — | 1 | - |
| CHEMBL192824 | — | — | 1 | - |
| CHEMBL190860 | — | — | 1 | - |
| CHEMBL143707 | — | — | 1 | - |
| CHEMBL188964 | — | — | 1 | - |
| CHEMBL363396 | — | — | 1 | - |
| CHEMBL195585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192619 | — | Ki | = | 2121.0 | nM | 5.67 |
| CHEMBL365812 | — | Ki | = | 2908.0 | nM | 5.54 |
| CHEMBL425010 | — | Ki | = | 3549.0 | nM | 5.45 |
| CHEMBL190937 | — | Ki | = | 3608.0 | nM | 5.44 |
| CHEMBL192528 | — | Ki | = | 4426.0 | nM | 5.35 |
| CHEMBL366170 | — | Ki | = | 5296.0 | nM | 5.28 |
| CHEMBL23034 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL106939 | DASB | Ki | > | 10000.0 | nM | - |
| CHEMBL22183 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL192824 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL190860 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL143707 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL188964 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL363396 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL195585 | — | Ki | > | 10000.0 | nM | - |