Assay Detail
Functional
CHEMBL838604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of 2-methyl-5-HT effect on 5-hydroxytryptamine 3 receptor in isolated guinea pig ileum
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Microwave assisted synthesis of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile as a new class of serotonin 5-HT3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 6.32 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL364128 | — | — | 1 | 8.20 |
| CHEMBL184379 | — | — | 1 | 7.40 |
| CHEMBL185472 | — | — | 1 | 7.10 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 6.90 |
| CHEMBL366109 | — | — | 1 | 6.50 |
| CHEMBL186775 | — | — | 1 | 6.00 |
| CHEMBL186532 | — | — | 1 | 5.70 |
| CHEMBL187181 | — | — | 1 | 5.40 |
| CHEMBL186813 | — | — | 1 | 5.10 |
| CHEMBL184511 | — | — | 1 | 4.90 |
| CHEMBL185458 | — | — | 1 | - |
| CHEMBL184650 | — | — | 1 | - |
| CHEMBL184241 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL364128 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL184379 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL185472 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL46 | ONDANSETRON | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL366109 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL186775 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL186532 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL187181 | — | Kd | = | 3981.07 | nM | 5.40 |
| CHEMBL186813 | — | Kd | = | 7943.28 | nM | 5.10 |
| CHEMBL184511 | — | Kd | = | 12589.25 | nM | 4.90 |
| CHEMBL185458 | — | Kd | = | 158489.32 | nM | - |
| CHEMBL184650 | — | Kd | = | 1258925.41 | nM | - |
| CHEMBL184241 | — | Kd | = | 125892.54 | nM | - |