Assay Detail
Functional
CHEMBL838607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive antagonism of Angiotensin II receptor in endothelium removed isolated rat aortic ring; (n = 5)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.42 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1016 | CANDESARTAN | 3.0 | 1 | 8.02 |
| CHEMBL339360 | — | — | 1 | 7.80 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.40 |
| CHEMBL7632 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1016 | CANDESARTAN | Kd | = | 9.55 | nM | 8.02 |
| CHEMBL339360 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL191 | LOSARTAN | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL7632 | — | Kd | = | 354.81 | nM | 6.45 |