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Assay Detail

CHEMBL838618

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory constant for Serotonin transporter
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
De Lucca GV, Kim UT, Vargo BJ, Duncia JV, Santella JB, Gardner DS, Zheng C, Liauw A, Wang Z, Emmett G, Wacker DA, Welch PK, Covington M, Stowell NC, Wadman EA, Das AM, Davies P, Yeleswaram S, Graden DM, Solomon KA, Newton RC, Trainor GL, Decicco CP, Ko SS.
J Med Chem (2005) 48 : 2194 -2211
PubMed 15771462 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 3 5.52 5.63

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL195433 1 5.63
CHEMBL250689 1 5.53
CHEMBL363840 1 5.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL195433 Ki = 2350.0 nM 5.63
CHEMBL250689 Ki = 2938.0 nM 5.53
CHEMBL363840 Ki = 3900.0 nM 5.41