Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL838642

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory constant for human cloned 5-HT4 receptor
ChEMBL ↗
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 4 (CHEMBL1875) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification.
Clark RD, Jahangir A, Alam M, Rocha C, Lin L, Bjorner B, Nguyen K, Grady C, Williams TJ, Stepan G, Tang HM, Ford AP.
Bioorg Med Chem Lett (2005) 15 : 1697 -1700
PubMed 15745824 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 10.01 10.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL180835 — — 1 10.80
CHEMBL181202 — — 1 10.60
CHEMBL361118 — — 1 10.60
CHEMBL367354 — — 1 10.50
CHEMBL182999 — — 1 10.50
CHEMBL181126 — — 1 10.50
CHEMBL180680 — — 1 10.30
CHEMBL424790 — — 1 10.30
CHEMBL180201 — — 1 10.20
CHEMBL360449 — — 1 10.10
CHEMBL360245 — — 1 10.00
CHEMBL180830 — — 1 10.00
CHEMBL178669 — — 1 9.90
CHEMBL179833 — — 1 9.90
CHEMBL178285 — — 1 9.90
CHEMBL180697 — — 1 9.80
CHEMBL181415 — — 1 9.80
CHEMBL181928 — — 1 9.70
CHEMBL180632 — — 1 9.60
CHEMBL356359 PIBOSEROD 2.0 1 9.60
CHEMBL360531 — — 1 9.60
CHEMBL179799 — — 1 9.50
CHEMBL362582 — — 1 9.40
CHEMBL182590 — — 1 9.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL180835 — Ki = 0.01585 nM 10.80
CHEMBL181202 — Ki = 0.02512 nM 10.60
CHEMBL361118 — Ki = 0.02512 nM 10.60
CHEMBL367354 — Ki = 0.03162 nM 10.50
CHEMBL182999 — Ki = 0.03162 nM 10.50
CHEMBL181126 — Ki = 0.03162 nM 10.50
CHEMBL180680 — Ki = 0.05012 nM 10.30
CHEMBL424790 — Ki = 0.05012 nM 10.30
CHEMBL180201 — Ki = 0.0631 nM 10.20
CHEMBL360449 — Ki = 0.07943 nM 10.10
CHEMBL360245 — Ki = 0.1 nM 10.00
CHEMBL180830 — Ki = 0.1 nM 10.00
CHEMBL178669 — Ki = 0.1259 nM 9.90
CHEMBL179833 — Ki = 0.1259 nM 9.90
CHEMBL178285 — Ki = 0.1259 nM 9.90
CHEMBL180697 — Ki = 0.1585 nM 9.80
CHEMBL181415 — Ki = 0.1585 nM 9.80
CHEMBL181928 — Ki = 0.1995 nM 9.70
CHEMBL180632 — Ki = 0.2512 nM 9.60
CHEMBL356359 PIBOSEROD Ki = 0.2512 nM 9.60
CHEMBL360531 — Ki = 0.2512 nM 9.60
CHEMBL179799 — Ki = 0.3162 nM 9.50
CHEMBL362582 — Ki = 0.3981 nM 9.40
CHEMBL182590 — Ki = 0.7943 nM 9.10