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Assay Detail

CHEMBL838644

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory constant towards 5-hydroxytryptamine 2A receptor (5-HT2A)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics.
Alvarado M, Coelho A, Masaguer CF, Raviña E, Brea J, Padín JF, Loza MI.
Bioorg Med Chem Lett (2005) 15 : 3063 -3066
PubMed 15878662 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 7.19 8.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL155486 1 8.57
CHEMBL365203 1 8.29
CHEMBL191068 1 8.23
CHEMBL42 CLOZAPINE 4.0 1 8.04
CHEMBL155257 1 8.02
CHEMBL421801 1 7.34
CHEMBL54 HALOPERIDOL 4.0 1 6.78
CHEMBL190292 1 6.65
CHEMBL189213 1 6.59
CHEMBL190509 1 6.54
CHEMBL189618 1 6.33
CHEMBL191408 1 6.15
CHEMBL190582 1 5.98
CHEMBL189562 1 -
CHEMBL191430 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL155486 Ki = 2.692 nM 8.57
CHEMBL365203 Ki = 5.129 nM 8.29
CHEMBL191068 Ki = 5.888 nM 8.23
CHEMBL42 CLOZAPINE Ki = 9.12 nM 8.04
CHEMBL155257 Ki = 9.55 nM 8.02
CHEMBL421801 Ki = 45.71 nM 7.34
CHEMBL54 HALOPERIDOL Ki = 165.96 nM 6.78
CHEMBL190292 Ki = 223.87 nM 6.65
CHEMBL189213 Ki = 257.04 nM 6.59
CHEMBL190509 Ki = 288.4 nM 6.54
CHEMBL189618 Ki = 467.74 nM 6.33
CHEMBL191408 Ki = 707.95 nM 6.15
CHEMBL190582 Ki = 1047.13 nM 5.98
CHEMBL189562 Ki < 10000.0 nM -
CHEMBL191430 Ki < 10000.0 nM -