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Assay Detail

CHEMBL838645

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory constant towards 5-hydroxytryptamine 2C receptor (5-HT2C)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics.
Alvarado M, Coelho A, Masaguer CF, Raviña E, Brea J, Padín JF, Loza MI.
Bioorg Med Chem Lett (2005) 15 : 3063 -3066
PubMed 15878662 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 6.53 7.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL42 CLOZAPINE 4.0 1 7.98
CHEMBL365203 1 7.06
CHEMBL191408 1 7.05
CHEMBL190582 1 6.90
CHEMBL191068 1 6.89
CHEMBL155486 1 6.89
CHEMBL155257 1 6.83
CHEMBL189213 1 6.35
CHEMBL189618 1 5.81
CHEMBL421801 1 5.79
CHEMBL190292 1 5.72
CHEMBL54 HALOPERIDOL 4.0 1 5.14
CHEMBL190509 1 -
CHEMBL189562 1 -
CHEMBL191430 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL42 CLOZAPINE Ki = 10.47 nM 7.98
CHEMBL365203 Ki = 87.1 nM 7.06
CHEMBL191408 Ki = 89.13 nM 7.05
CHEMBL190582 Ki = 125.89 nM 6.90
CHEMBL191068 Ki = 128.82 nM 6.89
CHEMBL155486 Ki = 128.82 nM 6.89
CHEMBL155257 Ki = 147.91 nM 6.83
CHEMBL189213 Ki = 446.68 nM 6.35
CHEMBL189618 Ki = 1548.82 nM 5.81
CHEMBL421801 Ki = 1621.81 nM 5.79
CHEMBL190292 Ki = 1905.46 nM 5.72
CHEMBL54 HALOPERIDOL Ki = 7244.36 nM 5.14
CHEMBL190509 Ki < 10000.0 nM -
CHEMBL189562 Ki < 10000.0 nM -
CHEMBL191430 Ki < 10000.0 nM -