Assay Detail
Binding
CHEMBL838677
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Inhibitory activity against cytosolic human carbonic anhydrase II
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.61 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.52 |
| CHEMBL221802 | — | — | 1 | 8.30 |
| CHEMBL183701 | — | — | 1 | 8.22 |
| CHEMBL182440 | — | — | 1 | 8.10 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL182276 | — | — | 1 | 8.08 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL182429 | — | — | 1 | 8.03 |
| CHEMBL353258 | — | — | 1 | 8.01 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL182455 | — | — | 1 | 7.84 |
| CHEMBL2113026 | — | — | 1 | 7.83 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL183240 | — | — | 1 | 7.82 |
| CHEMBL171476 | — | — | 1 | 7.61 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL68257 | — | — | 1 | 7.12 |
| CHEMBL361421 | — | — | 1 | 7.08 |
| CHEMBL181357 | — | — | 1 | 6.42 |
| CHEMBL170139 | — | — | 1 | 6.38 |
| CHEMBL181753 | — | — | 1 | 6.25 |
| CHEMBL360714 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL221802 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL183701 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL182440 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL182276 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL182429 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL353258 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL182455 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL2113026 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL183240 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL171476 | — | Ki | = | 24.5 | nM | 7.61 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL68257 | — | Ki | = | 76.3 | nM | 7.12 |
| CHEMBL361421 | — | Ki | = | 84.2 | nM | 7.08 |
| CHEMBL181357 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL170139 | — | Ki | = | 417.0 | nM | 6.38 |
| CHEMBL181753 | — | Ki | = | 563.0 | nM | 6.25 |
| CHEMBL360714 | — | Ki | = | 643.0 | nM | 6.19 |