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Assay Detail

CHEMBL838701

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for human adenosine A3 receptor
ChEMBL ↗
123
Total Activities
123
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A3 (CHEMBL256) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Combined target-based and ligand-based drug design approach as a tool to define a novel 3D-pharmacophore model of human A3 adenosine receptor antagonists: pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as a key study.
Moro S, Braiuca P, Deflorian F, Ferrari C, Pastorin G, Cacciari B, Baraldi PG, Varani K, Borea PA, Spalluto G.
J Med Chem (2005) 48 : 152 -162
PubMed 15634009 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 123 8.37 9.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL145767 — — 1 9.85
CHEMBL144979 — — 1 9.85
CHEMBL348975 — — 1 9.85
CHEMBL168018 — — 1 9.82
CHEMBL324735 — — 1 9.80
CHEMBL352796 — — 1 9.74
CHEMBL141550 — — 1 9.72
CHEMBL352073 — — 1 9.70
CHEMBL329791 — — 1 9.70
CHEMBL349240 — — 1 9.68
CHEMBL166684 — — 1 9.68
CHEMBL165224 — — 1 9.62
CHEMBL165083 — — 1 9.57
CHEMBL167753 — — 1 9.54
CHEMBL165778 — — 1 9.54
CHEMBL352345 — — 1 9.52
CHEMBL166301 — — 1 9.52
CHEMBL351285 — — 1 9.51
CHEMBL330286 — — 1 9.49
CHEMBL572765 — — 1 9.47
CHEMBL165560 — — 1 9.47
CHEMBL164905 — — 1 9.47
CHEMBL165600 — — 1 9.43
CHEMBL351075 — — 1 9.40
CHEMBL350261 — — 1 9.40
CHEMBL344501 — — 1 9.40
CHEMBL354161 — — 1 9.37
CHEMBL424161 — — 1 9.37
CHEMBL350205 — — 1 9.35
CHEMBL348925 — — 1 9.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL145767 — Ki = 0.14 nM 9.85
CHEMBL144979 — Ki = 0.14 nM 9.85
CHEMBL348975 — Ki = 0.14 nM 9.85
CHEMBL168018 — Ki = 0.15 nM 9.82
CHEMBL324735 — Ki = 0.16 nM 9.80
CHEMBL352796 — Ki = 0.18 nM 9.74
CHEMBL141550 — Ki = 0.19 nM 9.72
CHEMBL329791 — Ki = 0.2 nM 9.70
CHEMBL352073 — Ki = 0.2 nM 9.70
CHEMBL166684 — Ki = 0.21 nM 9.68
CHEMBL349240 — Ki = 0.21 nM 9.68
CHEMBL165224 — Ki = 0.24 nM 9.62
CHEMBL165083 — Ki = 0.27 nM 9.57
CHEMBL167753 — Ki = 0.29 nM 9.54
CHEMBL165778 — Ki = 0.29 nM 9.54
CHEMBL352345 — Ki = 0.3 nM 9.52
CHEMBL166301 — Ki = 0.3 nM 9.52
CHEMBL351285 — Ki = 0.31 nM 9.51
CHEMBL330286 — Ki = 0.32 nM 9.49
CHEMBL572765 — Ki = 0.34 nM 9.47
CHEMBL164905 — Ki = 0.34 nM 9.47
CHEMBL165560 — Ki = 0.34 nM 9.47
CHEMBL165600 — Ki = 0.37 nM 9.43
CHEMBL350261 — Ki = 0.4 nM 9.40
CHEMBL344501 — Ki = 0.4 nM 9.40
CHEMBL351075 — Ki = 0.4 nM 9.40
CHEMBL354161 — Ki = 0.43 nM 9.37
CHEMBL424161 — Ki = 0.43 nM 9.37
CHEMBL350205 — Ki = 0.45 nM 9.35
CHEMBL348925 — Ki = 0.46 nM 9.34
CHEMBL304726 — Ki = 0.48 nM 9.32
CHEMBL142562 — Ki = 0.5 nM 9.30
CHEMBL352192 — Ki = 0.5 nM 9.30
CHEMBL164509 — Ki = 0.51 nM 9.29
CHEMBL167915 — Ki = 0.55 nM 9.26
CHEMBL164647 — Ki = 0.56 nM 9.25
CHEMBL349611 — Ki = 0.57 nM 9.24
CHEMBL164325 — Ki = 0.6 nM 9.22
CHEMBL423934 — Ki = 0.6 nM 9.22
CHEMBL65271 — Ki = 0.6 nM 9.22
CHEMBL165910 — Ki = 0.65 nM 9.19
CHEMBL351211 — Ki = 0.7 nM 9.15
CHEMBL350042 — Ki = 0.71 nM 9.15
CHEMBL349954 — Ki = 0.72 nM 9.14
CHEMBL164686 — Ki = 0.74 nM 9.13
CHEMBL357663 — Ki = 0.8 nM 9.10
CHEMBL302765 — Ki = 0.8 nM 9.10
CHEMBL165620 — Ki = 0.8 nM 9.10
CHEMBL164992 — Ki = 0.8 nM 9.10
CHEMBL175922 — Ki = 0.82 nM 9.09