Assay Detail
Binding
CHEMBL838828
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Inhibitory constant determined against Norepinephrine transporter
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.79 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181188 | — | — | 3 | 8.77 |
| CHEMBL180101 | ESREBOXETINE | 3.0 | 1 | 8.72 |
| CHEMBL179249 | — | — | 1 | 8.08 |
| CHEMBL360985 | — | — | 1 | 7.75 |
| CHEMBL360901 | — | — | 1 | 6.96 |
| CHEMBL362269 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181188 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL180101 | ESREBOXETINE | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL179249 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL181188 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL360985 | — | Ki | = | 17.6 | nM | 7.75 |
| CHEMBL181188 | — | Ki | = | 24.6 | nM | 7.61 |
| CHEMBL360901 | — | Ki | = | 108.6 | nM | 6.96 |
| CHEMBL362269 | — | Ki | = | 364.3 | nM | 6.44 |