Assay Detail
Binding
CHEMBL838839
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant for human immunodeficiency virus type 1 protease
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 8.78 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1161736 | — | — | 1 | 10.30 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 10.10 |
| CHEMBL1161737 | — | — | 1 | 10.05 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.64 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 9.64 |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | 9.62 |
| CHEMBL1161741 | — | — | 1 | 9.52 |
| CHEMBL1161732 | — | — | 1 | 9.52 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 9.51 |
| CHEMBL1161734 | — | — | 1 | 9.40 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 9.27 |
| CHEMBL1161738 | — | — | 1 | 9.26 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 9.23 |
| CHEMBL1161742 | — | — | 1 | 9.22 |
| CHEMBL1161743 | — | — | 1 | 9.21 |
| CHEMBL1161733 | — | — | 1 | 9.10 |
| CHEMBL365756 | — | — | 1 | 8.92 |
| CHEMBL425182 | — | — | 1 | 8.85 |
| CHEMBL610244 | — | — | 1 | 8.85 |
| CHEMBL340616 | — | — | 1 | 8.51 |
| CHEMBL190112 | — | — | 1 | 8.25 |
| CHEMBL443 | SULFAMETHOXAZOLE | 4.0 | 1 | 8.00 |
| CHEMBL345603 | — | — | 1 | 7.43 |
| CHEMBL1161735 | — | — | 1 | 7.40 |
| CHEMBL150908 | — | — | 1 | 7.26 |
| CHEMBL1161739 | — | — | 1 | 5.62 |
| CHEMBL1161740 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1161736 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL729 | LOPINAVIR | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL1161737 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL114 | SAQUINAVIR | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL116 | AMPRENAVIR | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL1163 | ATAZANAVIR | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL1161741 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL1161732 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL1161734 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL584 | NELFINAVIR | Ki | = | 0.54 | nM | 9.27 |
| CHEMBL1161738 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL163 | RITONAVIR | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL1161742 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1161743 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL1161733 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL365756 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL425182 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL610244 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL340616 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL190112 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL443 | SULFAMETHOXAZOLE | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL345603 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL1161735 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL150908 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL1161739 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL1161740 | — | Ki | = | 5000.0 | nM | 5.30 |