Assay Detail
Binding
CHEMBL839160
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Binding inhibition constant was determined by inhibition of [125I]iodocyanopindolol binding to Beta-3 adrenergic receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.89 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184407 | — | — | 1 | 8.40 |
| CHEMBL361505 | — | — | 1 | 7.85 |
| CHEMBL188196 | — | — | 1 | 7.77 |
| CHEMBL185836 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184407 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL361505 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL188196 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL185836 | — | Ki | = | 30.0 | nM | 7.52 |