Assay Detail
Binding
CHEMBL839443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against blood clotting factor X
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.75 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367954 | — | — | 1 | 9.77 |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | -1.0 | 1 | 9.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367954 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | Ki | = | 0.19 | nM | 9.72 |