Assay Detail
Binding
CHEMBL839468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: orally active prostacyclin mimetics. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.79 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494 | ILOPROST | 4.0 | 1 | 8.19 |
| CHEMBL190497 | — | — | 1 | 7.92 |
| CHEMBL132589 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494 | ILOPROST | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL190497 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL132589 | — | Ki | = | 54.0 | nM | 7.27 |