Assay Detail
Binding
CHEMBL839520
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Binding affinity determined against human kallikrein
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.21 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176140 | — | — | 1 | 7.21 |
| CHEMBL554926 | — | — | 1 | - |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176140 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL554926 | — | Ki | > | 2300.0 | nM | - |
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | Ki | > | 2300.0 | nM | - |