Assay Detail
Binding
CHEMBL839523
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Inhibition constant against human carbonic anhydrase XII
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.71 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 8.47 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL3038236 | — | — | 2 | 8.23 |
| CHEMBL3038232 | — | — | 1 | 8.13 |
| CHEMBL3038233 | — | — | 1 | 8.07 |
| CHEMBL3038239 | — | — | 1 | 7.96 |
| CHEMBL3038234 | — | — | 1 | 7.92 |
| CHEMBL3038238 | — | — | 1 | 7.82 |
| CHEMBL195615 | — | — | 1 | 7.80 |
| CHEMBL3038237 | — | — | 1 | 7.77 |
| CHEMBL372497 | — | — | 1 | 7.72 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.66 |
| CHEMBL3038242 | — | — | 1 | 7.57 |
| CHEMBL193924 | — | — | 1 | 7.57 |
| CHEMBL3038240 | — | — | 1 | 7.54 |
| CHEMBL196697 | — | — | 1 | 7.52 |
| CHEMBL3038241 | — | — | 1 | 7.52 |
| CHEMBL373184 | — | — | 1 | 7.48 |
| CHEMBL197104 | — | — | 1 | 7.42 |
| CHEMBL196608 | — | — | 1 | 7.41 |
| CHEMBL197031 | — | — | 1 | 7.36 |
| CHEMBL193907 | — | — | 1 | 7.30 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.30 |
| CHEMBL381243 | — | — | 1 | 7.28 |
| CHEMBL193593 | — | — | 1 | - |
| CHEMBL370790 | — | — | 1 | - |
| CHEMBL3038235 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77517 | INDISULAM | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL3038236 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL3038232 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL3038233 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL3038239 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3038234 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL3038238 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL195615 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3038237 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL372497 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL193924 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3038242 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL3038240 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL196697 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3038241 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL373184 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL197104 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL196608 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL197031 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL193907 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL381243 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL193593 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL370790 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3038235 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL3038236 | — | Ki | > | 1000.0 | nM | - |