Assay Detail
Binding
CHEMBL839587
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Inhibitory activity against mitogen-activated protein kinase p38
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.66 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365359 | — | — | 1 | 8.80 |
| CHEMBL372301 | — | — | 1 | 8.74 |
| CHEMBL265032 | — | — | 1 | 8.68 |
| CHEMBL197041 | — | — | 1 | 8.22 |
| CHEMBL436291 | — | — | 1 | 8.15 |
| CHEMBL197096 | — | — | 1 | 8.14 |
| CHEMBL195188 | — | — | 1 | 8.04 |
| CHEMBL193992 | — | — | 1 | 7.99 |
| CHEMBL426466 | — | — | 1 | 7.69 |
| CHEMBL193563 | — | — | 1 | 7.53 |
| CHEMBL363600 | — | — | 1 | 7.50 |
| CHEMBL197267 | — | — | 1 | 7.25 |
| CHEMBL193494 | — | — | 1 | 7.18 |
| CHEMBL196295 | — | — | 1 | 6.75 |
| CHEMBL193983 | — | — | 1 | 6.15 |
| CHEMBL196847 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365359 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL372301 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL265032 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL197041 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL436291 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL197096 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL195188 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL193992 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL426466 | — | Ki | = | 20.4 | nM | 7.69 |
| CHEMBL193563 | — | Ki | = | 29.7 | nM | 7.53 |
| CHEMBL363600 | — | Ki | = | 31.8 | nM | 7.50 |
| CHEMBL197267 | — | Ki | = | 56.2 | nM | 7.25 |
| CHEMBL193494 | — | Ki | = | 65.9 | nM | 7.18 |
| CHEMBL196295 | — | Ki | = | 179.3 | nM | 6.75 |
| CHEMBL193983 | — | Ki | = | 709.0 | nM | 6.15 |
| CHEMBL196847 | — | Ki | = | 1772.0 | nM | 5.75 |