Assay Detail
Binding
CHEMBL839592
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Inhibition of Matrix metalloprotease-13 (MMP-13)
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.94 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363968 | — | — | 1 | 6.42 |
| CHEMBL185159 | — | — | 1 | 6.30 |
| CHEMBL359569 | — | — | 1 | 6.22 |
| CHEMBL184553 | — | — | 1 | 6.18 |
| CHEMBL185321 | — | — | 1 | 6.12 |
| CHEMBL184062 | — | — | 1 | 6.12 |
| CHEMBL364875 | — | — | 1 | 6.12 |
| CHEMBL184302 | — | — | 1 | 6.09 |
| CHEMBL185279 | — | — | 1 | 6.02 |
| CHEMBL365905 | — | — | 1 | 5.92 |
| CHEMBL184885 | — | — | 1 | 5.77 |
| CHEMBL363732 | — | — | 1 | 5.75 |
| CHEMBL185587 | — | — | 1 | 5.58 |
| CHEMBL182730 | — | — | 1 | 5.49 |
| CHEMBL184782 | — | — | 1 | 5.49 |
| CHEMBL365031 | — | — | 1 | 5.41 |
| CHEMBL363261 | — | — | 1 | - |
| CHEMBL361376 | — | — | 1 | - |
| CHEMBL184975 | — | — | 1 | - |
| CHEMBL184200 | — | — | 1 | - |
| CHEMBL184266 | — | — | 1 | - |
| CHEMBL183828 | — | — | 1 | - |
| CHEMBL185160 | — | — | 1 | - |
| CHEMBL434348 | — | — | 1 | - |
| CHEMBL183868 | — | — | 1 | - |
| CHEMBL184889 | — | — | 1 | - |
| CHEMBL364589 | — | — | 1 | - |
| CHEMBL185397 | — | — | 1 | - |
| CHEMBL185521 | — | — | 1 | - |
| CHEMBL359625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363968 | — | Ki | = | 377.0 | nM | 6.42 |
| CHEMBL185159 | — | Ki | = | 503.0 | nM | 6.30 |
| CHEMBL359569 | — | Ki | = | 603.0 | nM | 6.22 |
| CHEMBL184553 | — | Ki | = | 653.0 | nM | 6.18 |
| CHEMBL185321 | — | Ki | = | 753.0 | nM | 6.12 |
| CHEMBL184062 | — | Ki | = | 754.0 | nM | 6.12 |
| CHEMBL364875 | — | Ki | = | 753.0 | nM | 6.12 |
| CHEMBL184302 | — | Ki | = | 804.0 | nM | 6.09 |
| CHEMBL185279 | — | Ki | = | 955.0 | nM | 6.02 |
| CHEMBL365905 | — | Ki | = | 1206.0 | nM | 5.92 |
| CHEMBL184885 | — | Ki | = | 1708.0 | nM | 5.77 |
| CHEMBL363732 | — | Ki | = | 1758.0 | nM | 5.75 |
| CHEMBL185587 | — | Ki | = | 2613.0 | nM | 5.58 |
| CHEMBL182730 | — | Ki | = | 3266.0 | nM | 5.49 |
| CHEMBL184782 | — | Ki | = | 3266.0 | nM | 5.49 |
| CHEMBL365031 | — | Ki | = | 3869.0 | nM | 5.41 |
| CHEMBL362100 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL426434 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL184265 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL181807 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL363451 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL184942 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL183431 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL359625 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL185521 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL185397 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL364589 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL184889 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL183868 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL434348 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL185160 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL183828 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL184266 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL184200 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL184975 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL361376 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL363261 | — | Ki | > | 5000.0 | nM | - |