Assay Detail
Binding
CHEMBL839629
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Inhibitory constant against cloned human Gonadotropin-releasing hormone receptor stably expressed in HEK293 cells was determined
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.13 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321376 | — | — | 1 | 8.96 |
| CHEMBL2113012 | — | — | 1 | 8.64 |
| CHEMBL23830 | — | — | 1 | 7.47 |
| CHEMBL366701 | — | — | 1 | 7.43 |
| CHEMBL182284 | — | — | 1 | 7.05 |
| CHEMBL369723 | — | — | 1 | 6.92 |
| CHEMBL182145 | — | — | 1 | 6.66 |
| CHEMBL359741 | — | — | 1 | 6.42 |
| CHEMBL179953 | — | — | 1 | 6.39 |
| CHEMBL180352 | — | — | 1 | 5.38 |
| CHEMBL369101 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321376 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL2113012 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL23830 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL366701 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL182284 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL369723 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL182145 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL359741 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL179953 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL180352 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL369101 | — | Ki | > | 20000.0 | nM | - |