Assay Detail
Binding
CHEMBL839633
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Binding affinity for Norepinephrine transporter (NET) expressed in LCK PK1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LCK PK1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.36 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295467 | NISOXETINE | 2.0 | 1 | 8.80 |
| CHEMBL361259 | — | — | 1 | 7.95 |
| CHEMBL186056 | — | — | 1 | 7.77 |
| CHEMBL183470 | — | — | 1 | 7.70 |
| CHEMBL114275 | — | — | 1 | 6.63 |
| CHEMBL186962 | — | — | 1 | 6.54 |
| CHEMBL23034 | — | — | 1 | 6.16 |
| CHEMBL106939 | DASB | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295467 | NISOXETINE | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL361259 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL186056 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL183470 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL114275 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL186962 | — | Ki | = | 286.0 | nM | 6.54 |
| CHEMBL23034 | — | Ki | = | 699.0 | nM | 6.16 |
| CHEMBL106939 | DASB | Ki | > | 1000.0 | nM | - |