Assay Detail
Binding
CHEMBL839650
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Ability to displace [3H]spiperone from human Dopamine receptor D2S stably transfected in GH4C1 (rat pituitary) cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Pituitary gland cell |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.05 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361035 | — | — | 1 | 7.22 |
| CHEMBL426062 | — | — | 1 | 7.16 |
| CHEMBL187113 | — | — | 1 | 7.03 |
| CHEMBL184388 | — | — | 1 | 6.92 |
| CHEMBL360394 | — | — | 1 | 6.82 |
| CHEMBL185156 | — | — | 1 | 6.22 |
| CHEMBL187236 | — | — | 1 | 6.08 |
| CHEMBL366304 | — | — | 1 | 6.05 |
| CHEMBL360424 | — | — | 1 | 6.01 |
| CHEMBL364782 | — | — | 1 | 6.00 |
| CHEMBL187122 | — | — | 1 | 5.92 |
| CHEMBL186558 | — | — | 1 | 5.82 |
| CHEMBL366043 | — | — | 1 | 5.58 |
| CHEMBL184551 | — | — | 1 | 5.51 |
| CHEMBL427522 | — | — | 1 | 5.43 |
| CHEMBL183160 | — | — | 1 | 5.40 |
| CHEMBL182075 | — | — | 1 | 5.40 |
| CHEMBL424808 | — | — | 1 | 5.30 |
| CHEMBL187804 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361035 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL426062 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL187113 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL184388 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL360394 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL185156 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL187236 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL366304 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL360424 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL364782 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL187122 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL186558 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL366043 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL184551 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL427522 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL183160 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL182075 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL424808 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL187804 | — | Ki | = | 8000.0 | nM | 5.10 |