Assay Detail
Binding
CHEMBL839666
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Inhibition constant against human cathepsin B in fluorescence assay using Cbz-Phe-Arg-AMC
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Acyclic cyanamide-based inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.55 | 10.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190121 | — | — | 1 | 10.11 |
| CHEMBL191558 | — | — | 1 | 9.60 |
| CHEMBL371420 | — | — | 1 | 8.89 |
| CHEMBL189149 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190121 | — | Ki | = | 0.077 | nM | 10.11 |
| CHEMBL191558 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL371420 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL189149 | — | Ki | = | 2600.0 | nM | 5.58 |