Assay Detail
Binding
CHEMBL839686
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Inhibition of [3H]deltorphin II binding to delta and kappa opioid receptors expressed in HEK 293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Opioid receptors; delta & kappa (CHEMBL2095151) ↗| Type | SELECTIVITY GROUP |
| Organism | Homo sapiens |
Publication
A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.36 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610614 | — | — | 1 | 9.82 |
| CHEMBL611406 | — | — | 1 | 9.37 |
| CHEMBL611143 | — | — | 1 | 9.28 |
| CHEMBL610615 | — | — | 1 | 8.97 |
| CHEMBL367889 | — | — | 1 | - |
| CHEMBL175969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610614 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL611406 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL611143 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL610615 | — | Ki | = | 1.07 | nM | 8.97 |
| CHEMBL367889 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL175969 | — | Ki | > | 1000.0 | nM | - |