Assay Detail
Binding
CHEMBL839688
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Inhibition of [3H]NECA binding to human adenosine A3 receptor expressed in HeLa cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.04 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 8.40 |
| CHEMBL331372 | CGS-21680 | — | 1 | 7.17 |
| CHEMBL361925 | — | — | 1 | 7.08 |
| CHEMBL186113 | GW-328267 | 1.0 | 1 | 7.04 |
| CHEMBL2096798 | — | — | 1 | 7.00 |
| CHEMBL368880 | — | — | 1 | 6.89 |
| CHEMBL360837 | — | — | 1 | 6.85 |
| CHEMBL360646 | — | — | 1 | 6.54 |
| CHEMBL186403 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL331372 | CGS-21680 | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL361925 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL186113 | GW-328267 | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL2096798 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL368880 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL360837 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL360646 | — | Ki | = | 288.0 | nM | 6.54 |
| CHEMBL186403 | — | Ki | = | 400.0 | nM | 6.40 |