Assay Detail
Binding
CHEMBL839698
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Mean inhibitory constant towards human carbonic anhydrase V determined by spectrophotometric dansylamide binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.26 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.74 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.70 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 8.60 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 7.69 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 20.6 | nM | 7.69 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 25.4 | nM | 7.59 |