Assay Detail
Binding
CHEMBL839757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against Nicotinic acetylcholine receptor alpha3-beta4 expressed in xenopus oocytes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.32 | 4.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL134752 | DIMETHYLPHENYLPIPERAZINIUM | — | 1 | 4.72 |
| CHEMBL497939 | CYTISINICLINE | 3.0 | 1 | 4.14 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.10 |
| CHEMBL667 | ACETYLCHOLINE | 4.0 | 1 | - |
| CHEMBL293975 | — | — | 1 | - |
| CHEMBL371808 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL134752 | DIMETHYLPHENYLPIPERAZINIUM | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL497939 | CYTISINICLINE | EC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL3 | NICOTINE | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL667 | ACETYLCHOLINE | EC50 | = | 203000.0 | nM | - |
| CHEMBL293975 | — | EC50 | > | 1000000.0 | nM | - |
| CHEMBL371808 | — | EC50 | > | 1000000.0 | nM | - |