Assay Detail
Functional
CHEMBL839767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.70 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366208 | FTY720-P | -1.0 | 1 | 9.52 |
| CHEMBL114606 | — | — | 1 | 8.92 |
| CHEMBL190006 | — | — | 1 | 7.66 |
| CHEMBL314854 | FINGOLIMOD | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366208 | FTY720-P | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL114606 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL190006 | — | EC50 | = | 21.8 | nM | 7.66 |
| CHEMBL314854 | FINGOLIMOD | EC50 | > | 10000.0 | nM | - |