Assay Detail
Binding
CHEMBL839925
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant against HMG-CoA reductase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Molecular docking of the highly hypolipidemic agent alpha-asarone with the catalytic portion of HMG-CoA reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.42 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1496 | ROSUVASTATIN | 4.0 | 1 | 9.05 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 1 | 8.59 |
| CHEMBL50444 | MEGLUTOL | 2.0 | 1 | 7.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1496 | ROSUVASTATIN | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1064 | SIMVASTATIN | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL50444 | MEGLUTOL | Ki | = | 23.5 | nM | 7.63 |