Assay Detail
Binding
CHEMBL839942
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Binding affinity for human Alpha-1D adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of fluoro analogues of 8-{2-[4-(4-methoxyphenyl)piperazin-1yl]ethyl}-8-azaspiro[4.5]decane-7,9-dione as selective alpha(1d)-adrenergic receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.59 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299691 | — | — | 1 | 9.08 |
| CHEMBL556313 | — | — | 1 | 9.02 |
| CHEMBL98241 | — | — | 1 | 8.89 |
| CHEMBL13647 | BMY-7378 | — | 1 | 8.80 |
| CHEMBL193620 | — | — | 1 | 8.72 |
| CHEMBL446180 | — | — | 1 | 8.25 |
| CHEMBL192099 | — | — | 1 | 8.10 |
| CHEMBL57546 | — | — | 1 | 7.85 |
| CHEMBL274864 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299691 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL556313 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL98241 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL13647 | BMY-7378 | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL193620 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL446180 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL192099 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL57546 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL274864 | — | Ki | > | 124.0 | nM | - |