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Assay Detail

CHEMBL839947

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]DPDPE binding to recombinant human Opioid receptor delta 1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide.
MacDougall JM, Zhang XD, Polgar WE, Khroyan TV, Toll L, Cashman JR.
Bioorg Med Chem Lett (2005) 15 : 1583 -1586
PubMed 15745801 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 5 7.25 8.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL366917 1 8.14
CHEMBL359534 1 7.50
CHEMBL359644 1 7.25
CHEMBL1330 MORPHINE GLUCURONIDE 2.0 1 6.77
CHEMBL362202 DEPROTECTED COGENER OF M6G 1 6.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL366917 Ki = 7.2 nM 8.14
CHEMBL359534 Ki = 31.4 nM 7.50
CHEMBL359644 Ki = 56.2 nM 7.25
CHEMBL1330 MORPHINE GLUCURONIDE Ki = 170.0 nM 6.77
CHEMBL362202 DEPROTECTED COGENER OF M6G Ki = 266.3 nM 6.58