Assay Detail
Binding
CHEMBL839948
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Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 10.32 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189620 | — | — | 1 | 10.70 |
| CHEMBL185848 | — | — | 1 | 10.52 |
| CHEMBL76578 | — | — | 1 | 10.22 |
| CHEMBL365843 | — | — | 1 | 9.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189620 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL185848 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL76578 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL365843 | — | Ki | = | 0.15 | nM | 9.82 |