Assay Detail
Binding
CHEMBL839949
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Inhibitory constant against neuraminidase Influenza A virus A/N2/Tokyo strain
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Neuraminidase (CHEMBL2051) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) |
Publication
Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.66 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370047 | — | — | 1 | 7.70 |
| CHEMBL369125 | — | — | 2 | 7.43 |
| CHEMBL362993 | — | — | 1 | 7.35 |
| CHEMBL195156 | — | — | 1 | 7.12 |
| CHEMBL424821 | — | — | 1 | 6.82 |
| CHEMBL365976 | — | — | 1 | 6.57 |
| CHEMBL190819 | — | — | 1 | 6.57 |
| CHEMBL366026 | — | — | 1 | 6.52 |
| CHEMBL373336 | — | — | 1 | 6.51 |
| CHEMBL426810 | — | — | 1 | 6.46 |
| CHEMBL195288 | — | — | 1 | 6.46 |
| CHEMBL191512 | — | — | 1 | 6.41 |
| CHEMBL382322 | — | — | 1 | 6.38 |
| CHEMBL195871 | — | — | 1 | 6.21 |
| CHEMBL192279 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370047 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL369125 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL362993 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL195156 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL424821 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL369125 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL365976 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL190819 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL366026 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL373336 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL426810 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL195288 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL191512 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL382322 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL195871 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL192279 | — | Ki | = | 3000.0 | nM | 5.52 |