Assay Detail
Binding
CHEMBL839963
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]diprenorphine binding to human Opioid receptor kappa 1 expressed in chinese hamster ovary cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.60 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | 1.0 | 1 | 8.89 |
| CHEMBL290543 | — | — | 1 | 8.85 |
| CHEMBL3349979 | — | — | 1 | 8.49 |
| CHEMBL379138 | — | — | 1 | 8.31 |
| CHEMBL370272 | — | — | 1 | 8.14 |
| CHEMBL378635 | DEOXY SALVINORIN A | — | 1 | 8.10 |
| CHEMBL255969 | SALVINORIN A PROPYL ETHER | — | 1 | 7.54 |
| CHEMBL384411 | — | — | 1 | 7.54 |
| CHEMBL3349980 | — | — | 1 | 7.45 |
| CHEMBL3349984 | — | — | 1 | 7.22 |
| CHEMBL3349987 | — | — | 1 | 7.12 |
| CHEMBL3349983 | — | — | 1 | 7.08 |
| CHEMBL213567 | — | — | 1 | 7.04 |
| CHEMBL424698 | SALVINORIN B | — | 1 | 6.81 |
| CHEMBL413774 | — | — | 1 | 6.66 |
| CHEMBL3219942 | — | — | 1 | 6.33 |
| CHEMBL215076 | — | — | 1 | - |
| CHEMBL1644773 | — | — | 1 | - |
| CHEMBL3350046 | — | — | 1 | - |
| CHEMBL3349985 | — | — | 1 | - |
| CHEMBL3349986 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL290543 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL3349979 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL379138 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL370272 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL378635 | DEOXY SALVINORIN A | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL255969 | SALVINORIN A PROPYL ETHER | Ki | = | 28.7 | nM | 7.54 |
| CHEMBL384411 | — | Ki | = | 28.9 | nM | 7.54 |
| CHEMBL3349980 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL3349984 | — | Ki | = | 60.1 | nM | 7.22 |
| CHEMBL3349987 | — | Ki | = | 75.7 | nM | 7.12 |
| CHEMBL3349983 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL213567 | — | Ki | = | 90.9 | nM | 7.04 |
| CHEMBL424698 | SALVINORIN B | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL413774 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL3219942 | — | Ki | = | 462.0 | nM | 6.33 |
| CHEMBL215076 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL1644773 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3350046 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3349985 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3349986 | — | Ki | > | 10000.0 | nM | - |