Assay Detail
Binding
CHEMBL839969
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at melanocortin-1 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanocyte-stimulating hormone receptor (CHEMBL3795) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.44 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436122 | — | — | 1 | 6.00 |
| CHEMBL194987 | — | — | 1 | 5.17 |
| CHEMBL195110 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436122 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL194987 | — | Ki | = | 6800.0 | nM | 5.17 |
| CHEMBL195110 | — | Ki | = | 6900.0 | nM | 5.16 |