Assay Detail
Binding
CHEMBL839970
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Binding affinity at melanocortin-5 receptor stably transfected in HEK 293 cells using [125I]NDP-MSH as radiolabeled
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.31 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195110 | — | — | 1 | 6.80 |
| CHEMBL363576 | — | — | 1 | 6.52 |
| CHEMBL195308 | — | — | 1 | 6.46 |
| CHEMBL194987 | — | — | 1 | 6.46 |
| CHEMBL436122 | — | — | 1 | 6.25 |
| CHEMBL192464 | — | — | 1 | 6.17 |
| CHEMBL195071 | — | — | 1 | 6.14 |
| CHEMBL195734 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195110 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL363576 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL195308 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL194987 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL436122 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL192464 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL195071 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL195734 | — | Ki | = | 2300.0 | nM | 5.64 |