Assay Detail
Binding
CHEMBL839977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro displacement of [3H]nisoxetine from human norepinephrine transporter expressed in HEK293 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.78 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190860 | — | — | 1 | 6.85 |
| CHEMBL22183 | — | — | 1 | 6.49 |
| CHEMBL363396 | — | — | 1 | 6.30 |
| CHEMBL143707 | — | — | 1 | 6.18 |
| CHEMBL190937 | — | — | 1 | 6.10 |
| CHEMBL188964 | — | — | 1 | 6.02 |
| CHEMBL23034 | — | — | 1 | 5.87 |
| CHEMBL365812 | — | — | 1 | 5.42 |
| CHEMBL192528 | — | — | 1 | 5.41 |
| CHEMBL195585 | — | — | 1 | 5.36 |
| CHEMBL366170 | — | — | 1 | 5.35 |
| CHEMBL106939 | DASB | 1.0 | 1 | 5.29 |
| CHEMBL192824 | — | — | 1 | 5.15 |
| CHEMBL192619 | — | — | 1 | 5.12 |
| CHEMBL425010 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190860 | — | Ki | = | 141.7 | nM | 6.85 |
| CHEMBL22183 | — | Ki | = | 320.4 | nM | 6.49 |
| CHEMBL363396 | — | Ki | = | 505.0 | nM | 6.30 |
| CHEMBL143707 | — | Ki | = | 663.8 | nM | 6.18 |
| CHEMBL190937 | — | Ki | = | 787.4 | nM | 6.10 |
| CHEMBL188964 | — | Ki | = | 946.2 | nM | 6.02 |
| CHEMBL23034 | — | Ki | = | 1352.0 | nM | 5.87 |
| CHEMBL365812 | — | Ki | = | 3823.0 | nM | 5.42 |
| CHEMBL192528 | — | Ki | = | 3910.0 | nM | 5.41 |
| CHEMBL195585 | — | Ki | = | 4332.0 | nM | 5.36 |
| CHEMBL366170 | — | Ki | = | 4440.0 | nM | 5.35 |
| CHEMBL106939 | DASB | Ki | = | 5127.0 | nM | 5.29 |
| CHEMBL192824 | — | Ki | = | 7036.0 | nM | 5.15 |
| CHEMBL192619 | — | Ki | = | 7552.0 | nM | 5.12 |
| CHEMBL425010 | — | Ki | > | 10000.0 | nM | - |