Assay Detail
Binding
CHEMBL840036
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In vitro inhibition of [3H]NT binding to porcine striatal Neurotensin receptor 1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Evaluation of lactam-bridged neurotensin analogues adjusting psi(Pro10) close to the experimentally derived bioactive conformation of NT(8-13).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.59 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342252 | — | — | 1 | 9.57 |
| CHEMBL362127 | — | — | 1 | 7.92 |
| CHEMBL2310906 | — | — | 1 | 5.85 |
| CHEMBL186638 | — | — | 1 | 4.85 |
| CHEMBL434134 | — | — | 1 | 4.77 |
| CHEMBL186637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342252 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL362127 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2310906 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL186638 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL434134 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL186637 | — | Ki | > | 100000.0 | nM | - |