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Assay Detail

CHEMBL840037

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity measured against [14C]spermidine uptake in murine L1210 cancer cell line
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Expert

Target

L1210 (CHEMBL386)
Type CELL-LINE
Organism Mus musculus

Publication

N1-substituent effects in the selective delivery of polyamine conjugates into cells containing active polyamine transporters.
Gardner RA, Delcros JG, Konate F, Breitbeil F, Martin B, Sigman M, Huang M, Phanstiel O.
J Med Chem (2004) 47 : 6055 -6069
PubMed 15537360 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 5.52 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL536041 1 7.30
CHEMBL540098 1 5.96
CHEMBL536492 1 5.89
CHEMBL535594 1 5.80
CHEMBL535821 1 5.77
CHEMBL541629 1 5.75
CHEMBL556559 1 5.70
CHEMBL536725 1 5.54
CHEMBL535370 1 5.46
CHEMBL535603 1 5.42
CHEMBL537852 1 5.37
CHEMBL538321 1 5.35
CHEMBL536273 1 5.35
CHEMBL537630 1 4.90
CHEMBL558390 1 4.49
CHEMBL555288 1 4.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL536041 Ki = 50.0 nM 7.30
CHEMBL540098 Ki = 1100.0 nM 5.96
CHEMBL536492 Ki = 1300.0 nM 5.89
CHEMBL535594 Ki = 1600.0 nM 5.80
CHEMBL535821 Ki = 1700.0 nM 5.77
CHEMBL541629 Ki = 1800.0 nM 5.75
CHEMBL556559 Ki = 2000.0 nM 5.70
CHEMBL536725 Ki = 2900.0 nM 5.54
CHEMBL535370 Ki = 3500.0 nM 5.46
CHEMBL535603 Ki = 3800.0 nM 5.42
CHEMBL537852 Ki = 4300.0 nM 5.37
CHEMBL538321 Ki = 4500.0 nM 5.35
CHEMBL536273 Ki = 4500.0 nM 5.35
CHEMBL537630 Ki = 12700.0 nM 4.90
CHEMBL558390 Ki = 32200.0 nM 4.49
CHEMBL555288 Ki = 62300.0 nM 4.21