Assay Detail
Binding
CHEMBL840040
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Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assay
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.41 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.48 |
| CHEMBL417656 | — | — | 2 | 7.92 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 2 | 6.30 |
| CHEMBL177425 | — | — | 1 | 4.70 |
| CHEMBL283695 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL417656 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL417656 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL177425 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL283695 | — | Ki | = | 650000.0 | nM | - |