Assay Detail
Binding
CHEMBL840044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]- AB-MECA binding to human adenosine A3 receptor expressed in CHO cells
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.37 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113046 | — | — | 1 | 7.43 |
| CHEMBL187458 | — | — | 1 | 7.38 |
| CHEMBL363419 | — | — | 1 | 7.33 |
| CHEMBL188592 | — | — | 1 | 7.29 |
| CHEMBL366216 | — | — | 1 | 7.16 |
| CHEMBL188967 | — | — | 1 | 7.16 |
| CHEMBL2113045 | — | — | 1 | 7.13 |
| CHEMBL446698 | — | — | 1 | 6.91 |
| CHEMBL191270 | — | — | 1 | 6.87 |
| CHEMBL365026 | — | — | 1 | 6.47 |
| CHEMBL188345 | — | — | 1 | 6.38 |
| CHEMBL188343 | REVERSINE | — | 1 | 6.18 |
| CHEMBL190147 | — | — | 1 | 6.04 |
| CHEMBL188958 | — | — | 1 | 6.02 |
| CHEMBL191551 | — | — | 1 | 5.95 |
| CHEMBL188496 | — | — | 1 | 5.86 |
| CHEMBL426076 | — | — | 1 | 5.84 |
| CHEMBL188541 | — | — | 1 | 5.82 |
| CHEMBL362740 | — | — | 1 | 5.80 |
| CHEMBL191522 | — | — | 1 | 5.74 |
| CHEMBL364948 | — | — | 1 | 5.73 |
| CHEMBL427161 | — | — | 1 | 5.62 |
| CHEMBL187336 | — | — | 1 | 5.56 |
| CHEMBL187794 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113046 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL187458 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL363419 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL188592 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL366216 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL188967 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2113045 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL446698 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL191270 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL365026 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL188345 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL188343 | REVERSINE | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL190147 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL188958 | — | Ki | = | 960.0 | nM | 6.02 |
| CHEMBL191551 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL188496 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL426076 | — | Ki | = | 1460.0 | nM | 5.84 |
| CHEMBL188541 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL362740 | — | Ki | = | 1570.0 | nM | 5.80 |
| CHEMBL191522 | — | Ki | = | 1810.0 | nM | 5.74 |
| CHEMBL364948 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL427161 | — | Ki | = | 2420.0 | nM | 5.62 |
| CHEMBL187336 | — | Ki | = | 2770.0 | nM | 5.56 |
| CHEMBL187794 | — | Ki | = | 5400.0 | nM | 5.27 |