Assay Detail
Binding
CHEMBL840050
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Inhibition of [3H]U-69593 binding to Opioid receptor kappa 1
12
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, chemical synthesis, and biological evaluation of thiosaccharide analogues of morphine- and codeine-6-glucuronide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 4.65 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363976 | — | — | 1 | 4.96 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 4.33 |
| CHEMBL1330 | MORPHINE GLUCURONIDE | 2.0 | 1 | - |
| CHEMBL434900 | — | — | 1 | - |
| CHEMBL438373 | — | — | 1 | - |
| CHEMBL264244 | — | — | 1 | - |
| CHEMBL361491 | — | — | 2 | - |
| CHEMBL361921 | — | — | 1 | - |
| CHEMBL187225 | — | — | 1 | - |
| CHEMBL365900 | — | — | 1 | - |
| CHEMBL434723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363976 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL70 | MORPHINE | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL1330 | MORPHINE GLUCURONIDE | Ki | = | 4060000.0 | nM | - |
| CHEMBL434900 | — | Ki | = | 189000.0 | nM | - |
| CHEMBL438373 | — | Ki | = | 499000.0 | nM | - |
| CHEMBL264244 | — | Ki | = | 1390000.0 | nM | - |
| CHEMBL361491 | — | Ki | = | 2970000.0 | nM | - |
| CHEMBL361491 | — | Ki | = | 2190000.0 | nM | - |
| CHEMBL361921 | — | Ki | = | 288000.0 | nM | - |
| CHEMBL187225 | — | Ki | > | 10000000.0 | nM | - |
| CHEMBL365900 | — | Ki | = | 136000.0 | nM | - |
| CHEMBL434723 | — | Ki | = | 2480000.0 | nM | - |