Assay Detail
Binding
CHEMBL840051
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-MLA binding to alpha-7 nicotinic acetylcholine receptor of rat brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.72 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417278 | — | — | 1 | 6.23 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 6.11 |
| CHEMBL282473 | — | — | 1 | 4.82 |
| CHEMBL281410 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417278 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL3 | NICOTINE | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL282473 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL281410 | — | Ki | > | 100000.0 | nM | - |